From: Dr. Guillermo A. Morales (morales$##$combichemlab.com)
Date: Fri Jun 30 2000 - 00:49:11 EDT
Hi Raj,
I would recommend to you to make the fluorides instead. You can use the
reagent TFFH ( tetramethylfluoroformamidinium hexafluorophosphate) which now
is commercially available from PE Biosystems, Aldrich and Advanced ChemTech.
Here you have some references for the use of THHF:
1) Blackburn, C., A. Pingali, et al. (1997). “Libraries of Angiotensin
Converting Enzyme Inhinitors: Solid-Phase Synthesis and Affinity Selection.”
Bioorg. Med. Chem. Lett. 7: 823-826.
2) Vojkovsky, T., A. Weischel, et al. (1998). “Solid-Phase Synthesis of
Heterocycles Containing an 1-Acyl-3-oxopiperazine Skeleton.” J. Org. Chem.
63: 3162-3163.
3) Zhang, A. J., D. H. Russell, et al. (1998). “A Method for Removal of
N-BOC Protecting Groups from Substrates on TFA-sensitive Resins.”
Tetrahedron Letters 39: 7439-7442.
I hope this helps.
Guillermo.
-----
Guillermo A. Morales
E-mail: morales$##$combichemlab.com
Website: http://www.combichemlab.com
Member of the Combi-Web Consortium: http://www.combi-web.com
-----Original Message-----
From: owner-orglist$##$dq.fct.unl.pt [mailto:owner-orglist$##$dq.fct.unl.pt]On
Behalf Of rajan chaw
Sent: Friday, June 30, 2000 12:34 AM
To: Multiple recipients of list orglist
Subject: ORGLIST: Help needed
Dear orglist members,
Well I am seraching for references which gives
synthesis of FMOC and Boc chloride or anhydride which
i wanna try to synthesize myself in the lab to get a
feel of this chemistry,hence i am requesting all my
dear orglist members to help me out in this aspect and
i am really gratefull to everyone for the great help
they are extending to me for my understanding of this
subject.
Thanking everybody in advance for the help
Raj
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