From: Marko Hapke (marko.hapke$##$mail.uni-oldenburg.de)
Date: Thu Jun 15 2000 - 02:51:04 EDT
Hi!
I'm working on C-C coupling reactions using the Suzuki-Miyaura protocol
and in one case I used dimethyl 2-pyridylboronate as a coupling
component. I expected that the reaction should also be possible with the
free acid instead of using the ester. After some recherche in the
Beilstein databank and the literature there is no reference or
description of the pure 2-pyridine boronic acid ( C5H4NB(OH)2 ). Only
some early work from the 60's indicate the existence of the impure
compound (van Riel et al., Tetrahedron Lett., 1969, 3085). This is
interesting because of the commercial availability of te 3-pyridine
boronic acid and the 4-pyridine boronic acid. I would like to know if
someone came across this problem, too, or has worked on it and can give
me some suggestions concerning the synthesis and stability of the
compound.
Thanks!
Marko Hapke
University of Oldenburg
Germany
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