ORGLIST: 3-bromination of N-substituted pyrroles

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From: Gianluca Sbardella (merlino$##$uniroma1.it)
Date: Wed Jun 14 2000 - 04:14:30 EDT

Dear Colleagues,
first of all my apologies for any crossposting.
I recently planned to synthesize some 3-phenyl-N-substituted pyrroles
via Suzuki coupling of (substituted)benzene boronic acids with the
proper 3-bromo-pyrroles. Alas, the only method of 3-bromination of
pyrroles I found was an isomerization in a trifluoroacetic acid medium
of 2-bromo derivatives. Does anybody ever had any experence on this kind

of reaction?
Thank you very much in advance.
If the topic could be interesting for any other I will summarize to the
list.
Sincerely,

Dr. Gianluca Sbardella, Ph.D.
Diprtimento di Studi Farmaceutici
Universita' degli studi di Roma "La Sapienza"
Rome - Italy

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