ORGLIST: Mitsunobu Inversion

From: Yantao Chen (yanch$##$ifm.liu.se)
Date: Mon Jun 05 2000 - 10:32:27 EDT

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Hi,

Maybe everyone knows the Mitsunobu inversion procedure can make the secondary alcohol into the opposite configuration at the alcohol center. But sometimes the elimination will occurred when there is also a carbonyl group (beta position), in which case the unsaturated carbonyl compounds may be obtained instead through the loss of one water molecular. How to prevent this? My second question is : Can the aryl acid ester (eg. O2N-Ph-COOR) be hydrolyzed using K2CO3/MeOH without no water?

Thank you very much.

Yantao Chen
yanch$##$ifm.liu.se

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