From: Dr T Pathak (pathak$##$ems.ncl.res.in)
Date: Tue May 30 2000 - 05:58:23 EDT
Use 0.1% Et3N or some other easily removable base throughout if you are
using silica or alumina. Another useful method is to use Dowex/Amberlite
(H+) column if the aminoalcohol is the only amino group containing
material
in the mixture. Your compound will stick to the column and all other
components could be washed out. Then use ammonia solution as the eluent
and
collect your compound. I have used these techniques several times for
various polar amino compounds and found them very useful.
Good luck!
-----------------------------------------------------------------------------
Dr. Tanmaya Pathak Tel: (020)-589 33 00
Organic Chemistry Division (Synthesis) 589 33 15/16
National Chemical Laboratory extn.2055/2073
Pune 411 008 (020)-589 31 53
Maharasthra Fax: (020)-589 31 53
India e.mail: pathak$##$ems.ncl.res.in
-----------------------------------------------------------------------------
On Tue, 30 May 2000, zhaojk wrote:
> Dear all,
>
>
> Can anybody give me some advice on how to separate the amino alcohol compound
> by chromatography method? I use dimethylmethane and CH3OH as the developing
> solvent but I find it is difficult to wash them off from the SilGel collum? I
> change to Al2O3, but it does not work.
>
> As the polarity of the compound is too large(2 NH2 group and 2 OH group), I
> failed several times in the work. I am looking forwad to your reply.
>
>
> Sincerely yours
>
>
> Sunshine
>
>
> __________________
>
> ORGLIST - Organic Chemistry Mailing List
> Website / Archive / FAQ: http://www.orglist.net/
> List coordinator: Joao Aires de Sousa (jas$##$mail.fct.unl.pt)
>
__________________
ORGLIST - Organic Chemistry Mailing List
Website / Archive / FAQ: http://www.orglist.net/
List coordinator: Joao Aires de Sousa (jas$##$mail.fct.unl.pt)
This archive was generated by hypermail 2.1.4 : Fri Sep 19 2003 - 12:15:34 EDT