ORGLIST: replace HMPA

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From: Yantao Chen (yanch$##$ifm.liu.se)
Date: Wed May 24 2000 - 10:07:07 EDT

Dear All Members:

Maybe everyone knows that HMPA (hexamethylphosphoramide) is a good solvent during the alkylation of carbonyl compounds, especially used when the carbon anion was formed using LDA in THF. But due to its high toxicity, I am just wondering: is there anybody running the similar reaction with other kind of solvents?

Thanks in advance.

Yantao Chen
yanch$##$ifm.liu.se

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