ORGLIST: Re: None

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From: David L. Price (price$##$mail.chem.sc.edu)
Date: Tue Apr 25 2000 - 09:09:14 EDT

Bob,
    I've been studying non enzymatic glycation of proteins relevant to diabetes
and aging. One compound I've come across in 2,3-diaminophenazine (DAP) which
has been evaluated as an alternative to aminoguanidine (AG). AG was in the late
stages of human trials for the treatment of diabetic nephropathy when the trials
were terminated because of toxicity, possibly because of NO-synthase
inhibition. Some believe DAP can exhibit the same benefit as AG (the jury is
still out on exactly how and why AG works) without inhibiting NO-synthase.

T. Soulis, et al. Diabetologia (1999) 42: 472-479

David Price, graduate student
University of South Carolina
Department of Chemistry & Biochemistry

"Learn to Run, Run to Learn" -Angus Ogelbaine

"G. Robert Shelton" wrote:

> subscribers,
>
> ok i dont want to put up a false front like Mr. Coe's question. The question
> arises from a take home final for my synthesis class. it is your basic test,
> synthesis these four compound, but my question to you is what class of
> natural products / medicinal drugs have a di-amine funtionality on a fused
> ring system? The question arises from several papers ( in tetrahedron
> letters) that talk about the importance of this funtionality (the diamines)
> in natural products / medicine, but obviously due to the abreviated nature
> of papers in tet letts it doesnt give any examples or references.
>
> Thanks for any help this evening,
>
> Bob
>
> G. Robert Shelton
> Graduate Student
> University of Florida
> P.O. Box 117200
> 191 Leigh Hall
> Gainesville, FL 32611-7200
> "While stuck on this planet, take nothing but photographs, leave nothing
> but footprints, kill nothing but time."
>
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