Re: ORGLIST: Peptide bond formation from tfa salt

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From: David Gauthier (gauthier.david$##$videotron.ca)
Date: Thu Mar 23 2000 - 11:53:07 EST

Hi,
  I think that TEA will work, but you must find good references first. Try
these :
JACS (98) p.12783
Chem.Europ.J.En (99) p.79
Tet.(88) p.2359
Tet.(99) p.3511
JOC (99) p.4324

Good luck
David Gauthier
University of Sherbrooke

Christopher Paul Borella wrote:

> Hello,
> I have a simple question, I have generated a TFA salt of a free amine, and
> want to couple it with an acid chloride insitu. I can't seem to find any
> reference for this reaction, there are plenty with HCl salts but not
> TFA. Would TEA be strong enough to break up this salt or do I need to do
> something else? A co-worker sugested exchanging it to the HCl salt by
> reacting with excess HCl, however my compound is not stable to those
> conditions (silyl protecting groups). I would appreciate it if someone
> could give me some advise as to how to solve this or at least point me to
> a reference.
>
> Thanks,
>
> Chris
>
>
>
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>
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