Re: ORGLIST: Re: Peptide bond formation from tfa salt

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From: Research Scholars,tpr (tprscrs$##$uohyd.ernet.in)
Date: Thu Mar 23 2000 - 15:41:14 EST

Hello Chris,
i think you know, in peptide bond formation, if you're going to use
amino acid chloride to couple with you will loose the chirality of the
acid part.
good luck
palas gangopadhyay
>
>chris's message:

> Hello,
> I have a simple question, I have generated a TFA salt of a free amine, and
> want to couple it with an acid chloride insitu. I can't seem to find any
> reference for this reaction, there are plenty with HCl salts but not
> TFA. Would TEA be strong enough to break up this salt or do I need to do
> something else? A co-worker sugested exchanging it to the HCl salt by
> reacting with excess HCl, however my compound is not stable to those
> conditions (silyl protecting groups). I would appreciate it if someone
> could give me some advise as to how to solve this or at least point me to
> a reference.
>
> Thanks,
>
> Chris
>
>
>
>
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