From: Luis Fernando Garcia Alles (luis.garciaalles$##$ibc.unibe.ch)
Date: Thu Mar 23 2000 - 04:19:00 EST
Dear people,
I am considering the synthesis of some analogue of PEP (phosphoenol
pyruvate: Pi-O-C(=CH2)COOH) where the phosphoryl group (Pi) is missing.
Initially, if we remove the Pi group from this molecule, the enolate form
produced would immediately tautomerize to the ketone form (let us say
pyruvate, CH3-COCOOH). However, I would like to design and synthesize some
analogue where the enolate form would be more favoured, more populated than
the ketonic form, that is, it would exist mainly as the following specie:
R-CH=C(OH)COOH
Do you know of any R group, or do you have any other idea that might help
to stabilize this enolic form??. Any idea will be wellcome...
Well, thank you very much for whatever you might suggest me to do!!!
Have a very good time!!
=====================================
Luis Fernando García Alles, Ph.D.
Departement für Chemie und Biochemie
Universität Bern
Freiestrasse 3
CH-3012 Bern, Schweiz
Tel. ++41 (0)31/631 37 92
Fax ++41 (0)31/631 33 83
E-mail :garcia$##$ibc.unibe.ch
=====================================
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