ORGLIST: Synthesis of propiolic acid

From: Alison og Thomas Høyer (alihoyer$##$mobilixnet.dk)
Date: Mon Feb 28 2000 - 15:24:54 EST

• Next message: Alison og Thomas Høyer: "ORGLIST: Yields"
• Previous message: Jack Kellum: "Re: ORGLIST: Re: Pre-Work-Up Yields"

 Two reliable syntheses of propiolic acid are:

1) Oxidation of propargyl alcohol with Chromiumn trioxide in dilute sulfuric acid. Work up details are important, as propiolic acid is very water soluble.

2) Carbonation of acetylenic anion (Lithium or magnesium) with carbon dioxide.

No matter what, the name to look out for is L.Brandsma. He has pubnlished numerous extremely reliable synthesis involving acetylenic compounds of all sorts.

Yours

Thomas Høyer

__________________

ORGLIST - Organic Chemistry Mailing List
Website and Archive: http://www.orglist.net/
List coordinator: Joao Aires de Sousa (jas$##$mail.fct.unl.pt)

• Next message: Alison og Thomas Høyer: "ORGLIST: Yields"
• Previous message: Jack Kellum: "Re: ORGLIST: Re: Pre-Work-Up Yields"

This archive was generated by hypermail 2.1.4 : Fri Sep 19 2003 - 12:15:34 EDT