Re: ORGLIST: Synthesis of amidines...

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From: Jacob Zabicky (zabicky$##$bgumail.bgu.ac.il)
Date: Wed Jan 19 2000 - 05:04:17 EST

Hello Gianluca,

Possibly a Ritter-type process will do, treating the nitrile with dry HCl,
possibly in dry ethanol, followed by treatment with dry ammonia. I used the
method to prepare o-cyanophenylacetamide by applying water in the second
step.

All the best,

Jacob

>Dear colleagues,
>first of all I apologize for any crossposting.
>
>I need to synthesyze a few acetamidines (above all
>cyclopentylacetamidine and 2,6-difluorophenylacetamidine).
> Do you have any experience or suggestion concerning this topic?
>
>Thank you very much in advance,
>
>Dr. Gianluca Sbardella, Ph.D.
>Universita' degli studi di Roma "La Sapienza"
>Dipartimento di Studi Farmaceutici
>Rome - Italy
>
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>
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>List coordinator: Joao Aires de Sousa (jas$##$mail.fct.unl.pt)

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Prof. Jacob Zabicky Tel. 972-7-6461271/6461062/6472754
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