> Dear ORGLISTers,
> I want to resolve a racemic mixture of a carboxylic acid derivative.
> Do you know any non-enzymatic method ?
> If I use an enzymatic method would you predict better results with amides or esters ?
> TIA,
> Albert Simon

Thanks to all that answered my question suggesting the reaction of the acid with a chiral base and separation of the resulting distereoisomeric salts by crystalisation. (Or amidation with a chiral amine and separation of the resulting diastereoisomers.)

However I had a different approach in mind. I meant an enantiospecific reaction that would hydrolyse one of the enantiomers faster than the other. Any suggestion ?

I will summarize the answers I get.

Thanks to all !

A. Simon

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