Re: ORGLIST: Pharmaceutically accepted acids for salts

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From: Richard Prankerd (richard$##$pharmacy.uq.edu.au)
Date: Tue Nov 30 1999 - 07:14:46 EST

Another well-known pharmaceutical nitrate salt is thiamine
mononitrate, which is more stable in the solid state than the HCl,
despite the propensity of thiamine to undergo oxidation. The
mononitrate is less water-soluble than the HCl, which probably
accounts for its increased solid state stability, according to the
theory that virtually all solid-state drug degradation occurs in
adsorbed films of moisture.

Regards
Richard

>There are many pharmaceuticals listed as nitrate salts, so, probably your
>objection rises no problem. Nitric acid and some of its inorganic salts are
>also listed as pharmaceuticals. Examples:
>
>Methylatropine nitrate
>Miconazole nitrate
>Pilocarpine nitrate
>
>All the best,
>
>Jacob
>
>
> >
> >I seriously doubt that nitric acid would be of any value for the
>preparation of
> >pharmaceutically accepted salts, because of its ability to easily oxidize
> >organic compounds.
>

Richard J. Prankerd, PhD
Senior Lecturer
School of Pharmacy
University of Queensland Phone: INT + (617) 3365-3179
St Lucia QLD 4072 Fax: INT + (617) 3365-1688
AUSTRALIA richard$##$uqpharmacy.pharmacy.uq.edu.au
                        http://www.uq.edu.au/pharmacy/academic.html
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