ORGLIST: Synthesis of 3,4-dihydroxy-pyrrolidine

From: Dr. T.P. Radhakrishanan-(RS) (tprscrs$##$uohyd.ernet.in)
Date: Mon Sep 27 1999 - 14:36:28 EDT

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Hi all,
is it possible to synthesise chiral 3,4-dihydroxy-pyrrolidine from
tartaric acid... keeping the inbuilt chirality present in tartaric
acid...?
my plan was to protect the two -OH groups in tartaric acid first, then
formation of imide and subsequent reduction ( is it possible to reduce
with LAH? ) and deprotection should end up with 3,4 dihydroxy pyrrolidine.
can any body give me any suggesion about that?
thanks in advance
palas gangopadhyay
School of Chemistry
university of Hyderabad
Hyderabad-500 046
email tprscrs$##$uohyd.ernet.in


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