Re: ORGLIST: Separation Method

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From: Jacob Zabicky (zabicky$##$bgumail.bgu.ac.il)
Date: Tue Sep 21 1999 - 03:09:30 EDT

Hello Martin,

You may try dry column chromatography to do the job; it's quite economical
in time and materials, it does not require much experience to carry it out,
and probably the best, if unsuccessful you easily recover your stuff. With
the polar solvents you probably need for the mentioned compounds, ordinary
preparative columns of both alumina and silica get inactivated and also get
slightly dissolved. With the dry column technique you don't desorb your
compounds in a lengthy eluting operation, but you cut the enriched sections
and recover your compounds from the cuttings.

Have fun,

Jacob


>I am attempting to separate two compounds, both of which have a
>quaternary amine and a carboxylic acid at the end of a linker.
>One is residual reactant; 1-(4-carboxybutyl)-4-methyl-quinoline
>and the other is my product;
>1-(4-Carboxybutyl)-4-(3-methyl-2,3-dihydro-(benzo-1,3-oxazole)-2-methyliden
>e)-quinolinium
>bromide [oxazole yellow with the same carboxybutyl tail].
>
>What is a good method to separate these compounds?
>Thanks,
>Martin
>
>--
>Martin Thompson
>Arizona State University
>Department of Chemistry and Biochemistry
>http://www.public.asu.edu/~nordic/
>ICQ# 42402052
>__________________
>
>ORGLIST - Organic Chemistry Mailing List
>Website and Archive: http://www.orglist.net/
>List coordinator: Joao Aires de Sousa (jas$##$mail.fct.unl.pt)

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Prof. Jacob Zabicky Tel. 972-7-6461271/6461062/6472754
Institutes for Applied Research Fax. 972-7-6472969
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