From: Jacob Zabicky (zabicky$##$bgumail.bgu.ac.il)
Date: Wed Sep 15 1999 - 04:05:19 EDT
Hello Priya,
Something like this can be suggested to start with: Mount your apparatus on
the roof using a beaker as reaction vessel, and when the sun is strong add
your bromine solution dropwise. You work out the details of a proper
solvent (best a dry one), and the probable need to neutralize the HBr
byproduct. You may start with a few mg of substrate and Br2, and if the
thing works you scale it up.
Have fun!
Jacob
>Hello
>I am Priya Joshi, a Ph.D student. I am having difficulty in bromination of
>Methyl-2,4-dimethoxyphenylacetate. I want the bromination at the alpha
>position (i.e. at benzylic position).But when I tried NBS, bromination
>occurred at the Benzene ring.
>
>Does anybody know How to bring about benzylic bromination without ring
>bromination.
>
>Thanks
>
>Priya Joshi
>
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