Re: ORGLIST: deprotection of carbamate

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From: David.O-Dell-1 (dko$##$ou.edu)
Date: Tue Apr 20 1999 - 14:41:47 EDT

Yajima et al. have investigated a procedure that uses a mixture of TMSOTf=
, TFA
and thioanisole. Yajima, H. et al. 1988. Tetrahedron 44(3):805-819.

Cheers,

David O'Dell
Dept. of Chem. Univ. of Oklahoma

DUFRASNE FRANCOIS wrote:

> Hello to everybody,
>
> I've synthetised a primary amine protected by a carbethoxy group. I wan=
t now
> to hydrolyse it under the mildest conditions as possible. A colleague g=
ave
> me the advise to use the trifluoroacetic acid method, in dichloromethan=
e.
> Does anyone know a reference about it?
>
> Thanks in advance.
>
> DUFRASNE FRANCOIS
> Assistant professor
> Laboratoire de Chimie Pharmaceutique Organique
> Université Libre de Bruxelles, Institut de Pharmacie
> Boulevard du triomphe, Campus Plaine, CP 205/5
> 1050 Brussels Belgium
> Tél. 00+2+650.52.35 Fax 00+2+650.52.49
>
> __________________
>
> ORGLIST - Organic Chemistry Mailing List
> WWW Homepage and Archive: http://www.orglist.net/
> List coordinator: Joao Aires de Sousa (jas$##$mail.fct.unl.pt)

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