ORGLIST: deprotection of carbamate

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From: DUFRASNE FRANCOIS (dufrasne$##$ulb.ac.be)
Date: Tue Apr 20 1999 - 13:09:18 EDT

Hello to everybody,

I've synthetised a primary amine protected by a carbethoxy group. I want now
to hydrolyse it under the mildest conditions as possible. A colleague gave
me the advise to use the trifluoroacetic acid method, in dichloromethane.
Does anyone know a reference about it?


Thanks in advance.



DUFRASNE FRANCOIS
Assistant professor
Laboratoire de Chimie Pharmaceutique Organique
Université Libre de Bruxelles, Institut de Pharmacie
Boulevard du triomphe, Campus Plaine, CP 205/5
1050 Brussels Belgium
Tél. 00+2+650.52.35 Fax 00+2+650.52.49

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