From: Christelle Marmillon (chris_marmillon$##$yahoo.fr)
Date: Fri Nov 27 1998 - 11:44:49 EST
I'am PhD Student, and I'am looking for the mechanism of the following reaction (Reaction Scheme by attach document).
There is no Guanidine formation after reaction between an amine and N-Cbz-2-methylthio-3,4,5,6-tetrahydropyrimidine under basic condidtions. Using amine hydrochloride and the same isothiourea, guanidine is formed with ~60% yield.
Any idea about this mechanism can help me
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