ORGLIST: Propargyl bromide

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From: Dr. Michael Fassbender (mifa$##$nac.ac.za)
Date: Tue Jul 21 1998 - 09:16:09 EDT


Hello everybody,

does anyone know how to obtain propargyl bromide from acetylene (ethyne)?

My suggestion is the formation of acetylide with a sodium solution in liquid
ammonia in the first place (1.) , with can subsequently converted into the
desired pb (HC#C-CH2-Br) by SN with dibromo methane (2.):

1. HC#CH + NaNH2 --NH3(l)-> HC#C|
2. HC#C| + Br-CH2-Br -> HC#C-CH2-Br

Is this going to work?

Thanks in advance for your input!

Michael Fassbender

===============================================
Dr. Michael Fassbender
Radioisotope Production Group: Organic Chemistry
National Accelerator Centre (NAC)
P.O. Box 72
7131 Faure
South Africa

Phone: +27-21-843-3820 (business), +27-21-855-0056 (private)
Fax: +27-21-843-3901
email: mifa$##$nac.ac.za

===============================================

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