Re: ORGLIST - orglist Digest - V01 #142

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From: Jacob Zabicky (zabicky$##$bgumail.bgu.ac.il)
Date: Sun May 17 1998 - 02:41:06 EDT



>I am a chemistry student and am currently trying to do some organic
>synthesis. I wish to purify my 2,5-Dimetoxyaniline as it appears to me
>that my compound has been partially oxidised. Iwould greatly appreciate
>if anybody can give me some information(/reference) regarding the above
>matter.

>I would think that you could form the hydrochloride salt of the desired
>aniline and recrystallize it away from the oxidation product.
>
>I would expect the first oxidation to occure at the nitrogen, to make
>1-nitro-2,5-dimethoxybenzene. This would not form a hydrochloride salt and
>should be fairly soluable in organic solvents.
>
>So, why do you want to clean up your 2,5-DMA? What are you planning on
>doing with the material?

If the prodduct doesnt look to messy, say it's quite fluid but dark, I
would try a vacuum distillation. However, be careful! If you use a
microcapillary for boiling regulation, connect it to a vessel full with
nitrogen to avoid oxidation of the distillate both in the boiling flask and
the receiving vessels.

All the best

Jacob Zabicky


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Prof. Jacob Zabicky Tel. 972-7-6461271/6461062/6472754
Institutes for Applied Research Fax. 972-7-6472969
Ben-Gurion University of the Negev Private: POB 12366 Beer-Sheva 84836
POB 653, Beer-Sheva 84105, ISRAEL Tel. 972-7-6496792
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