ORGLIST: Bromination of 2-chloro-4-nitrotoluene

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From: Antonello Mai and Gianluca Sbardella (r.ragno$##$caspur.it)
Date: Fri Mar 06 1998 - 01:53:02 EST


Dear colleagues,
first of all my apologies for any repetition.

A few days ago I tried to brominate 2-chloro-4-nitrotoluene with NBS in
CCL4 as a solvent to achieve the corresponding benzylbromide. Together
with the desired product the reaction yelded some 1,1-dibromo-derivative
(the amount was straightly proportional with reaction temperature).
Does anybody know any other more selective brominating agent?

Many thanks in advance,

Gianluca Sbardella, Ph.D.
University of Rome "La Sapienza"
Dept. Pharmaceutical studies

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