ORGLIST: RE:None(hydrolysis)

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From: B (PXK12345$##$niftyserve.or.jp)
Date: Tue Jun 17 1997 - 23:37:00 EDT


>i've been trying to hydrolyse the ester, ethyl (4,5-dicyanoimidazole)-1-yl

How about LiOH at 50oC. LiOH is, as you know, very mild base and would
be compatible with many functionalities, including nitriles.

Aonther possibility is, hydrolysis of the esters under neutral
condition can be achieved with many enzymes. For the removal of acetate,
lipase works fairely nicely. (Lipase is frequently used not only to
introduce chirality, but alse to hydrolyse acetates in the presence of
other esters.)
For your substrate, the ester is Ethyl ester of large carboxylic acid.
Therefore, lipase would not work. In that case, try esterase (porcine
liver esterase.)
Esterase is rather expensive, but should be more promising than lipase.

Hope this helps.
M.Fujiwhara
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