ORGLIST: Reduction with TiCl3 - summary

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From: by way of Joao Aires de Sousa (r.ragno$##$
Date: Thu Jun 12 1997 - 03:04:50 EDT

Dear colleagues,
a few days ago I posted to OrgList and OrgChem a message asking about
titanium chloride. It's my wish to thank Ian Newington, Eric Lucas and
Tony Herlt for their kind and useful answers.
The original question was:

Dear colleagues, some times ago I read an article by Christopher J.
Moody et al. (J. Chem. Soc. Perkin Trans I '90, 673-679) in which it
was described the reduction of an aromatic nitro group by using a
Titanium (III) Chloride 15% solution-ammonium acetate buffer-acetone
system. Does anybody know if there is a review regarding the use of
titanium trichloride?

Here you are the answers I got:

There is a general review of low-valent titanium
chemistry by John E. McMurry in Acc. Chem Res., 1974, 7(9), 281-6.
Professor McMurry has done a lot of work in this area.

Ian Newington

Kodak European R&D, Headstone Drive, Harrow, HA1 4TY, UK
Tel: +44-(0)181-424-4451 FAX: +44-(0)181-424-5788



I know of reviews of lower-valent (presumably Ti(0)) reagents like
McMurry's, but I'm unfamiliar with reviews of the reducing powers of

Could you make sure to post anything you find out? I'm interested.

                Eric Lucas


The Encyclopaedia of Reagents for Organic Synthesis, ed L.A. Paquette,
1995, vol 7, pp 4911-4913 gives a brief review of the uses of TiCl3.


Tony Herlt,
Research School of Chemistry
Australian National University
ACT 0200
e-mail: herlt$##$

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