Re: ORGLIST: S-alkylation of 2-thiouracil

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From: by way of Joao Aires de Sousa (alihoyer$##$inet.uni-c.dk)
Date: Tue Mar 18 1997 - 17:01:01 EST


Dear Gianluca,

What was the product of the reaction?

> Dear colleagues,
> I've synthesized many 6-substituted-2-alkylthio-4-oxo-pyrimidines by
> S-alkylation of 2-thiouracils with alkyl halides and potassium carbonate
> in DMF, but when I tried to introduce the cyclopropyl group in the same
> way (i.e. with cyclopropyl iodide) I failed. Do you have any suggestion?
> I'll summarize to the list the answers I'll get.
> Thank you in advance,
>
> Gianluca " Blue Merlin" Sbardella
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