ORGLIST: S-alkylation of 2-thiouracil

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From: by way of Joao Aires de Sousa (r.ragno$##$caspur.it)
Date: Tue Mar 18 1997 - 02:50:13 EST


Dear colleagues,
I've synthesized many 6-substituted-2-alkylthio-4-oxo-pyrimidines by
S-alkylation of 2-thiouracils with alkyl halides and potassium carbonate
in DMF, but when I tried to introduce the cyclopropyl group in the same
way (i.e. with cyclopropyl iodide) I failed. Do you have any suggestion?
I'll summarize to the list the answers I'll get.
Thank you in advance,

Gianluca " Blue Merlin" Sbardella

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    * Dr. Gianluca Sbardella E-mail: r.ragno$##$caspur.it *
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    * "Il destino e' quel che e', non c'e' scampo piu' per me.." *
    * (Gene Wilder, "Frankenstein Junior") *
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